Carboxylesterase (CES)
Carboxylesterase; Carboxylic-ester Hydrolase
Cboxylesterases (CES) are serine hydrolases belonging to the superfamily of proteins with α/β hydrolase fold. Cboxylesterases are widely distributed in many tissues including liver, intestine, lung and kidney. Cboxylesterases catalyze the ester cleavage of a large number of structurally diverse ester- or amide-containing substrates into the corresponding alcohol and carboxylic acid. Actually, Cboxylesterases can hydrolyze ester, thioester, amide, and carbamate linkages in a wide variety of endo- and xenobiotic compounds, thus playing key roles in both endobiotic metabolism, and in activation and/or detoxification of xenobiotics. In humans, three Cboxylesterases have been identified, namely human carboxylesterase 1 (CES1), CES2, and CES3. Among them, CES1 and CES2 are two widely studied isoenzymes involved in xenobiotic metabolism. Cboxylesterases play an important role in the metabolism of various xenobiotics including ester drugs and environmental toxicants, and also participate in lipid homeostasis[1].
Carboxylesterase (CES) Isoform Specific Products
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Carboxylesterase (CES) Related Products (58)
Related Products (58)
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Carboxylesterase (CES) Isoform Comparison
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Nevadensin (Standard)
0 ImagesSynonyms: Lysionotin (Standard)Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.
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Oseltamivir acid methyl ester hydrochloride
0 ImagesCat. No.: HY-147331ACAS No.: 208720-78-9Oseltamivir acid methyl ester hydrochloride is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester hydrochloride is converted to oseltamivir acid by carboxylesterase 1 (CES1).
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Human CES2 Enzyme
0 ImagesCat. No.: HY-E70599Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome.
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Tripropionin
0 ImagesCat. No.: HY-W275793CAS No.: 139-45-7Synonyms: Glycerol tripropionateTripropionin (Glycerol tripropionate) is a triglyceride that can be hydrolyzed by carboxylic esterase from carrots. Tripropionin can serve as the oil phase for constructing high-performance lipid nanoemulsion droplets, enabling efficient encapsulation of Combretastatin A4 (HY-N2146) to achieve its stable storage and controlled release.
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WZU-13
0 ImagesWZU-13 is an inhibitor for Carboxylesterase (CES). WZU-13 inhibits 77% CES activity at a dose of 100 μM.
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Carboxylesterase-IN-1
0 ImagesCat. No.: HY-141834CAS No.: 2609018-59-7Carboxylesterase-IN-1, a novel pesticide, exhibits inhibitory action on carboxylesterase at 50 μg/mL similar to the known inhibitor triphenyl phosphate.
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SQ-24798
0 ImagesCat. No.: HY-129748CAS No.: 70873-80-2SQ-24,798 is a compound that inhibits carboxypeptidase B with high affinity and specificity. Its inhibitory effect may be achieved through the binding of the sulfhydryl group to the zinc ion of the enzyme and specific side chains.
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Notum pectinacetylesterase-1
0 ImagesCat. No.: HY-148360CAS No.: 460727-10-0Notum pectinacetylesterase-1 is a potent inhibitor of notum pectinacetylesterase. Notum pectinacetylesterase-1 can be used for the research of disorders affecting the bone.
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Bis(4-nitrophenyl) phosphate (Standard)
0 ImagesCat. No.: HY-W013205RCAS No.: 645-15-8Synonyms: BNPP (Standard)Bis(4-nitrophenyl) phosphate (Standard) is the analytical standard of Bis(4-nitrophenyl) phosphate. This product is intended for research and analytical applications. Bis(4-nitrophenyl) phosphate (BNPP) is an esterase inhibitor, inhibits the activity of esterases such as carboxylesterase. Bis(4-nitrophenyl) phosphate inhibits the degradation of Abiraterone in fresh plasma. Bis(4-nitrophenyl) phosphate can be used as a substrate to determine the enzymatic activity of phosphodiesterase in the roots of wetland plants. Bis(4-nitrophenyl) phosphate also acts as a catalyst for metallomicelles and a catalyst that promotes ring-opening polymerization (ROP).
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Miltirone (Standard)
0 ImagesCat. No.: HY-N1951RCAS No.: 27210-57-7Synonyms: Rosmariquinone (Standard)Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro).
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Heptenophos
0 ImagesCat. No.: HY-120042CAS No.: 23560-59-0Heptenophos is an inhibitor of AChE and plasma carboxylesterase (CES). By inhibiting AChE activity, Heptenophos causes the accumulation of acetylcholine at cholinergic synapses, thereby triggering typical symptoms of organophosphate poisoning. Heptenophos exhibits rapid lethal toxicity in male albino mice, but its toxic effects are effectively antagonized by obidoxime, and Memantine (HY-B0591) further enhances the detoxification efficacy of obidoxime. Therefore, Heptenophos is commonly used in studies related to the mechanism of organophosphate poisoning and detoxification strategies.
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WWL113 (Standard)
0 ImagesCat. No.: HY-110148RCAS No.: 947669-86-5WWL113 (Standard) is the analytical standard of WWL113 (HY-110148). This product is intended for research and analytical applications. WWL113 is a selective and orally active Ces3 and Ces1f inhibitor, with IC50 values of 120 nM and 100 nM for Ces3 and Ces1f, respectively. WWL113 appears to show excellent selectivity for the 60-Kda serine hydrolase (or hydrolases).
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Ethyl phenylglyoxylate (Standard)
0 ImagesSynonyms: Ethyl benzoylformate (Standard); Phenylglyoxylic acid ethyl ester (Standard)Ethyl phenylglyoxylate (Ethyl benzoylformate) (Standard) is the analytical standard of Ethyl phenylglyoxylate (HY-W016618). This product is intended for research and analytical applications. Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions.
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Notum-IN-2
0 ImagesCat. No.: HY-182402CAS No.: 2411969-28-1Notum-IN-2 is a partially brain-penetrant Notum carboxyl-esterase inhibitor with an IC50 of 18 nM. Notum-IN-2 can be used as a chemical tool for exploring Wnt signalling in cells.
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Dihydromethysticin (Standard)
0 ImagesCat. No.: HY-N0921RCAS No.: 19902-91-1Synonyms: (+)-Dihydromethysticin (Standard)Dihydromethysticin (Standard) is the analytical standard of Dihydromethysticin (HY-N0921). This product is intended for research and analytical applications. Dihydromethysticin is an orally active natural active ingredient. Dihydromethysticin can be extracted from Piper methysticum. Dihydromethysticin inhibits carboxylesterase 1 (Ki = 68.2 μM) and CYP2A5. Dihydromethysticin upregulates NLRC3 and induces Apoptosis. Dihydromethysticin exhibits anticancer activity against colorectal cancer and lung adenoma.
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Carboxylesterase 2-IN-1
0 ImagesCat. No.: HY-184061CAS No.: 2590661-64-4Carboxylesterase 2-IN-1 is a potent carboxylesterase CES2 inhibitor with an IC50 of 0.13 μM. Carboxylesterase 2-IN-1 blocks the hydrolysis of fluorescein diacetate by CES2 via non-competitive inhibition. Carboxylesterase 2-IN-1 also effectively inhibits adipogenesis induced in mouse preadipocytes.
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Dibutyl malate
0 ImagesCat. No.: HY-W143997CAS No.: 6280-99-5Synonyms: DL-Malic acid dibutyl esterDibutyl malate is a substrate of carboxylesterase.
